The refereeing during Barca's historic 6-1 win over PSG in the second leg of their last 16 tie of this year's compe ion has also been queried, with suggestions it favoured the LaLiga giants as they staged their remarkable comeback.
But Pique wondered why there was so much made about his team, and not Madrid's win in Milan.
"When have I been favoured by referees? In the Champions League? I thought it was the league," he said after Spain's friendly win over France.
"We are discussing a historic comeback of 6-1 and focus on the referees.
"When Madrid win a Champions League with an offside goal from Ramos, nothing is said."
And also:
"I've nothing against Real Madrid players but there are other things about the club that I don't like. It rankles with me to see the individual who is involved with the indictment of Messi and Neymar sitting in the VIP section of the Santiago Bernabeu stadium.
It's always been like that at Madrid...cases against Messi, Neymar...and nothing for Cristiano [Ronaldo]. Same as always..."