Cancer cured by HIV

[ElNono]

New leukemia treatment exceeds 'wildest expectations' (http://www.msnbc.msn.com/id/44090512/#.TkREsmagToA)

[MannyIsGod]

Pretty damn amazing. As the podcast I heard it on pointed out though - isn't this how I am Legend started? :lol

[Cant_Be_Faded]

Pretty damn amazing. As the podcast I heard it on pointed out though - isn't this how I am Legend started? :lol

That is exactly what i first thought of

[LnGrrrR]

Ha! Take that you f'ing virus! We'll use you to cure cancer! BWAHAHAHA!

[vy65]

Wait. This wasn't a joke?

[SA210]

wow

[Trainwreck2100]

yes let's make smarter HIV, cause that has no possibility of fucking us over

[TeyshaBlue]

Pretty damn amazing. As the podcast I heard it on pointed out though - isn't this how I am Legend started? :lol

No shit! Jumped at me too.:toast:lol

[DeadlyDynasty]

Not sure what to think of this. Very interesting stuff, though

[ElNono]

My uncle was 'devoured' by leukemia in a little over a year, about 5 years ago. It's really an awful condition, and any development for a cure is welcome news.

[Trainwreck2100]

I can just imagine the attempt to get funding for this

"you wanna cure cancer with AIDS?"

[Trainwreck2100]

Magic Johnson's probably like "shit yeah i can't get cancer"

[Wild Cobra]

I heard that people were cured last night on the radio. Thanx for the details. I wonder if a variety will kill all forms of cancer.

What if...

AIDS was a result of a failed cancer experiment years ago?

[MannyIsGod]

Oh jesus here we go.

[DeadlyDynasty]

I can just imagine the attempt to get funding for this

"you wanna cure cancer with AIDS?"

HIV and AIDS are not the same thing, but I see your point.

[DeadlyDynasty]

I heard that people were cured last night on the radio. Thanx for the details. I wonder if a variety will kill all forms of cancer.

What if...

AIDS was a result of a failed cancer experiment years ago?

Not cancer...polio experiments in the Belgian Congo in the late 1950's. Look up Hilary Kaprowski.

[Spursfan092120]

Not cancer...polio experiments in the Belgian Congo in the late 1950's. Look up Hilary Kaprowski.

Been debunked, bro..sorry...even Koprowski said it wasn't the case..

http://en.wikipedia.org/wiki/OPV_AIDS_hypothesis

[DeadlyDynasty]

Been debunked, bro..sorry...even Koprowski said it wasn't the case..

http://en.wikipedia.org/wiki/OPV_AIDS_hypothesis

Of course Koprowski would deny it...who wants to claim credit for the biggest tragedy of the 20th century?

Here's something not from wikipedia, written by a journalist who's investigated the case for over 20 years:

http://www.aidsorigins.com/content/view/214/2/

[DeadlyDynasty]

btw, the accepted explanation of the origin of aids by the scientific community is the bushmeat theory. Basically it says that hunters in africa contracted HIV/SIV from chimps while eating them/cutting them up. That's cool and all--but if it were true then HIV/AIDS would've shown up hundreds of years ago--but there's obviously no evidence of that.

[Wild Cobra]

Of course Koprowski would deny it...who wants to claim credit for the biggest tragedy of the 20th century?

Here's something not from wikipedia, written by a journalist who's investigated the case for over 20 years:

http://www.aidsorigins.com/content/view/214/2/
There would have to be significant genetic similarities. That is not the case. Back then, genetics wasn't known so well. Today, we know that theory is wrong.

[boutons_deux]

These cancers were cured not by HIV but by genetic engineering of the patients' white blood cells so the immune system would attack the cancer cells as foreign rather than recognize them as endogenous.

This has been the dream of immunologists for several years.

It will be a dream for cancer patients for many, many years.

[boutons_deux]

btw, provenge is another immunological treatment. $90K+ for adding 4 months of life.

[baseline bum]

btw, the accepted explanation of the origin of aids by the scientific community is the bushmeat theory. Basically it says that hunters in africa contracted HIV/SIV from chimps while eating them/cutting them up. That's cool and all--but if it were true then HIV/AIDS would've shown up hundreds of years ago--but there's obviously no evidence of that.

mjFeYGAmhro

[fraga]

Somebody fucked a monkey...

[Spursfan092120]

mjFeYGAmhro

Ricky Gervais is hilarious.

[mouse]

Somebody fucked a monkey...

Thank you for explaining how koriwhat was conceived.

[Trainwreck2100]

So upon reading the article again, it appears that they used the intrusive aspect of HIV to inject genes in white blood cells to selectively target cancer cells.

[cheguevara]

well we don't know when exactly HIV showed up. Ppl would die of pnemonia or something like that and nobody knew it was AIDS.

The HIV was "discovered" in the 80s. But it easily could have been around since the turn of the century.

[Agloco]

So upon reading the article again, it appears that they used the intrusive aspect of HIV to inject genes in white blood cells to selectively target cancer cells.

This is definitely the path down which future cancer research will go. Molecular targeting and reconbinant DNA technologies.

Cancer, in a generic sense is simply a wound healing response gone awry. It involves an altered epithelial-stroma response. In normal inflammatory responses, macrophages mediate the repair process along with feedback from myofibroblasts.

My question is, what kind of WBC was injected and how large was the proliferative response? Where or how do those agressive scavengers get dealt with after the cancer is gone? Do they begin attacking other tissues eventually? Oh well, for future studies.......

For those that didn't catch it, they fought the primary leukemia by inducing a secondary one. Interesting. I'll be looking into this one.

[boutons_deux]

"Where or how do those agressive scavengers get dealt with after the cancer is gone?"

http://www.wisegeek.com/how-does-the-human-body-eliminate-dead-cells.htm

There is a catastrophic reaction when a high tumor load gets killed. The massive load of dead tumor cells overwhelms the disposal/excretion mechanisms. There is a term for it, but I can't find it now.

[Agloco]

Edit: I wasn't clear enough earlier.

:lol


Neither was I.

[boutons_deux]

The aggressive scavengers aren't the problem, since they only scavenge foreign/dead cells (unless you have an auto-immune disease).

What they are talking about is genetic engineering to achieve targeted immuno-therapy, for the modified immune system to attack the cancer cells as foreign.

[cheguevara]

Magic is already on the phone trying to get in on this program and get nonstop cancer patient ass

[Agloco]

The aggressive scavengers aren't the problem, since they only scavenge foreign/dead cells (unless you have an auto-immune disease).

What they are talking about is genetic engineering to achieve targeted immuno-therapy, for the modified immune system to attack the cancer cells as foreign.

Ya. I'm familiar with it. I was wondering if the mechanism (getting rid of the scavengers) is through the reticuloendothelial system or not. My question was related to the ability of the RES to recognize the altered macrophages.

ie, whats the nature of the transformation? Is it membrane expression, internal machinery, a combo? Neat discovery tbh.

[LnGrrrR]

I think the more pertinent question is, even if the leftover cells are harmful, are they as harmful as the cancer cells?

[DarkReign]

An even better question, IMO, is exactly how fast this treatment will be squashed by the FDA/Surgeon General and ultimately never make it to market if even the slightest side effect is found.

[boutons_deux]

I don't think it will be squashed.

It will be DELAYED by BigPharma-captured FDA for many, many years since it obviously threatens the huge profits of the "cancer industry" (chemo, and other useless, harmful crap).

UPenn will sell the license/patent to some BigPharma company as a monopoly,who will abuse the monopoly with exorbitant prices, $100K+.

This is another area where the Feds could drive down drug costs and overall sick-care costs.

The Feds would buy/own all patented drugs, and contract out the manufacture. Drug price would be something for the Feds to finance further patents, something for the mfrs.

Drug developers/researchers would not be drug mfrs/marketers. If their drug worked, they'd get a one time patent fee, or maybe a tiny license fee for a few years.

Radical? yes, because the current system is totally a rotten rip-off, with BigPharma spending more on marketing than on development.

[ElNono]

An even better question, IMO, is exactly how fast this treatment will be squashed by the FDA/Surgeon General and ultimately never make it to market if even the slightest side effect is found.

Or how badly big pharma will lobby for that end result...

EDIT: boutons beat me to it

[Agloco]

I don't think it will be squashed.

It will be DELAYED by BigPharma-captured FDA for many, many years since it obviously threatens the huge profits of the "cancer industry" (chemo, and other useless, harmful crap).

UPenn will sell the license/patent to some BigPharma company as a monopoly,who will abuse the monopoly with exorbitant prices, $100K+.

This is another area where the Feds could drive down drug costs and overall sick-care costs.

The Feds would buy/own all patented drugs, and contract out the manufacture. Drug price would be something for the Feds to finance further patents, something for the mfrs.

Drug developers/researchers would not be drug mfrs/marketers. If their drug worked, they'd get a one time patent fee, or maybe a tiny license fee for a few years.

Radical? yes, because the current system is totally a rotten rip-off, with BigPharma spending more on marketing than on development.

There's no money in a cure.

[boutons_deux]

Health care is a privilege (you have to pay dearly for), not a right. -- WC

Health care is where America is a World Champion Loser, can't even play in the same league with other industrial countries with national health care/insurance systems. And those systems AIN'T FREE. you pay a deduction on your paycheck,including a deduction from you unemployment "paycheck" (which is bigger and longer in other coutries).

Then it's CHEAP when you need it, and you don't live in fear of a medical catastrophe wiping you and your family out financially. So you go get health care when you need it, you don't put it off until the disease is 10x or 100x more severe.

btw, in these countries, certain things are excluded, like dental, hearing, eye glasses, and they all have thriving for-profit insurers for those who can affored 5-star coverage and want to buy queue-jumping for non-threatening problems.

Absolutely everybody serious about America's fucked up for-profit sick-care system should watch this:

http://www.pbs.org/wgbh/pages/frontline/sickaroundtheworld/

[DUNCANownsKOBE]

btw, the accepted explanation of the origin of aids by the scientific community is the bushmeat theory. Basically it says that hunters in africa contracted HIV/SIV from chimps while eating them/cutting them up. That's cool and all--but if it were true then HIV/AIDS would've shown up hundreds of years ago--but there's obviously no evidence of that.
You must not know Dave Chappelle has explained that people got AIDS from having sex with monkeys.

[Wild Cobra]

Does anyone know the research details? I believe it is standard practice for a corporation to fund such experiments, and have the first option to the rights when something pans out.

[boutons_deux]

RTFM

"Both the National Cancer Institute and several pharmaceutical companies declined to pay for the research. Neither applicants nor funders discuss the reasons an application is turned down. But good guesses are the general shortage of funds and the concept tried in this experiment was too novel and, thus, too risky for consideration."

"The researchers did manage to get a grant from the Alliance for Cancer Gene Therapy, a charity founded by Barbara and Edward Netter after their daughter-in-law died of cancer. The money was enough to finance the trials on the first three patients."

===

Wasn't it in PA a few years that immuno-therapy killed a boy by anaphylaxis?

[fraga]

http://mobi-wall.brothersoft.com/files/320240/i/12823574404300.jpg

I love this idea!!!

[DarkReign]

I don't think it will be squashed.

It will be DELAYED by BigPharma-captured FDA for many, many years since it obviously threatens the huge profits of the "cancer industry" (chemo, and other useless, harmful crap).

UPenn will sell the license/patent to some BigPharma company as a monopoly,who will abuse the monopoly with exorbitant prices, $100K+.

This is another area where the Feds could drive down drug costs and overall sick-care costs.

The Feds would buy/own all patented drugs, and contract out the manufacture. Drug price would be something for the Feds to finance further patents, something for the mfrs.

Drug developers/researchers would not be drug mfrs/marketers. If their drug worked, they'd get a one time patent fee, or maybe a tiny license fee for a few years.

Radical? yes, because the current system is totally a rotten rip-off, with BigPharma spending more on marketing than on development.

You know, youre a wild beast and all, but I actually really like your idea.

[Trainwreck2100]

Does anyone know the research details? I believe it is standard practice for a corporation to fund such experiments, and have the first option to the rights when something pans out.

:lol not reading article

[Agloco]

:lol not reading article

:lol surprised?

[Fabbs]

Or how badly big pharma will lobby for that end result...

EDIT: boutons beat me to it
Could foreign countries with treatment centers that are not in the death-greed industry some how find out how to make it?
Or Penn has it locked up?

[ElNono]

No idea.

[RandomGuy]

btw, the accepted explanation of the origin of aids by the scientific community is the bushmeat theory. Basically it says that hunters in africa contracted HIV/SIV from chimps while eating them/cutting them up. That's cool and all--but if it were true then HIV/AIDS would've shown up hundreds of years ago--but there's obviously no evidence of that.

Remember, AIDS is not like a cold, and requires some pretty substantial amounts of contact to really spread.

Actually is has shown up a while ago, and the evidence says it has been around for almost a century.

It was isolated to few individuals deep, deep in a jungle and far away from the outside world. Human civilization creeping into the crevices of the globe finally brought it out of its isolation.


Using HIV-1 sequences preserved in human biological samples along with estimates of viral mutation rates, scientists calculate that the jump from chimpanzee to human probably happened during the late 19th or early 20th century, a time of rapid urbanisation and colonisation in equatorial Africa. Exactly when the zoonosis occurred is not known. Some molecular datation studies suggest that HIV-1 group M had its most recent common ancestor (MRCA) (that is, started to spread in the human population) in the early 20th century, probably between 1915 and 1941.[12][13][14] A study published in 2008, analyzing viral sequences recovered from a recently-discovered biopsy made in Kinshasa, in 1960, along with previously-known sequences, suggested a common ancestor between 1873 and 1933 (with central estimates varying between 1902 and 1921).


A recent serological survey showed that human infections by SIV are not rare in Central Africa: the percentage of people showing seroreactivity to antigens - evidence of current or past SIV infection - was 2.3% among the general population of Cameroon, 7.8% in villages where bushmeat is practiced, and 17.1% in the most exposed people of these villages.[22] How the SIV virus would have transformed into HIV after infection of the hunter or bushmeat handler from the ape/monkey is still a matter of debate, although natural selection would favor any virions capable of adjusting so that they could infect and reproduce in the T cells of a human host.

http://en.wikipedia.org/wiki/Origin_of_AIDS

Immuno dificiency viruses have been with us for a while.

[jacobdrj]

On House once they used Herpes to slow the progress of cancer...

On House once...