Cruz didn't lose New York, Pennsylvania or Indiana because of Kasich and Trump would have won Ohio if he wasn't in the race. Rubio was an unpopular senator as well.
The general election will be no different in this respect because the people who care about republican endorsements aren't going to pull a different lever. Look at all the Ryan got from his own party for hesitating in his endorsement and Trump is attack republican governors and congressmen left and right
Nobody cares, this cycle will be about who appeals to the people not the party.

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I will bet you $500 Trump loses PA by 5 points or more