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FDA says you can't have it
laugh it up, no lives matter to you.Novavax showed greater efficacy against all circulating omicron variants than even the omicron specific mrna boosters
but you're not allowed to get it unless you're unvaxxed
FDA says you can't have it
why is that funny to you?FDA says you can't have it
ST everybody crew sounding off
& Biden has the con...1,052,000 Americans dead in the ground of the COVID.
& counting!!!
7.21.2022
Warp Speed 2.0, tbh
Can't happen soon enough.
https://erictopol.substack.com/p/the...e-boiling-frogWhy do I remain optimistic? Because SARS-CoV-2 is a much easier virus to prevail over than influenza. We have never had a flu vaccine with 95% efficacy; we’re lucky to have multivalent ones that are 40% effective. Tamiflu is a weak hitter compared with Paxlovid. The virus’s main protease (Mpro) makes for an enviable choke point to take it down SARS-CoV-2, even though resistance to the drug from mutations in Mpro will likely manifest in the months ahead. Although the mutations with functional consequences have been considerable with SARS-CoV-2, they are minimal compared with the head of the influenza virus. Variant-proof ‘universal’ coronavirus vaccines and nasal vaccines to block transmission and infection are our way to turn off the heat and get ahead of the virus’s evolutionary arc. We know what we need to do; we’re just not doing it. The boiling frog metaphor is contributing to the lack of taking action.
& Biden has the con...1,053,000 Americans dead in the ground of the COVID.
& counting!!!
7.22.2022
Phase III trials done for Bharat Biotech intranasal vaccine. Further tests needed to verify whether the vaccine has any sterilizing effect.
https://www.financialexpress.com/lif...otech/2630960/
Paxlovid great for people 65 and older, younger folks, not so much, according to one study.
https://www.usatoday.com/story/news/...ts/7889907001/Pfizer's COVID-19 pill appears to provide little or no benefit for younger adults, while still reducing the risk of hospitalization and death for high-risk seniors, according to a large study published Wednesday.
The results from a 109,000-patient Israeli study are likely to renew questions about the U.S. government's use of Paxlovid, which has become the go-to treatment for COVID-19 due to its at-home convenience. The Biden administration has spent more than $10 billion purchasing the drug and making it available at thousands of pharmacies through its test-and-treat initiative.
The researchers found that Paxlovid reduced hospitalizations among people 65 and older by roughly 75% when given shortly after infection. That's consistent with earlier results used to authorize the drug in the U.S. and other nations.
But people between the ages of 40 and 65 saw no measurable benefit, according to the analysis of medical records.
The study has limitations due to its design, which compiled data from a large Israeli health system rather than enrolling patients in a randomized study with a control group — the gold standard for medical research.
Worked wonders for Fauci and Biden.
BTW R.I.P old man tholdren. Played with fire raving in Brazil and paid the price.
He's not HemisfairBoomer?BTW R.I.P old man tholdren. Played with fire raving in Brazil and paid the price.
Vaccines mitigate transmission according to this study, prior infection works about half as well.
(This study relates to Omicron.)
https://www.nature.com/articles/d41586-022-02328-0The team found that among individuals with COVID-19, those who received at least one vaccine shot were 24% less likely to infect close contacts— in this case cellmates — compared with unvaccinated prisoners. People who had been infected before were 21% less likely to infect others compared with prisoners with no prior infection, and those who had been both vaccinated and previously infected were 41% less likely to pass on the virus compared with unvaccinated individuals without a previous infection.
[Nathan Lo, an infectious-disease researcher at the University of California, San Francisco] says he is surprised at the dose–response relationships; each vaccine dose a person has had reduced the risk of passing on the virus by a further 12%, on average. How recently people had been vaccinated was also important. For every 5 weeks that passed since a person’s last vaccine dose, the risk of transmitting the infection to a close contact increased by 6%.
Burr and Inhofe are right, Warp Speed 2.0 is way overdue
https://www.inhofe.senate.gov/newsro...variants-arise
oh yeah. thats where the decline of vaccine confidence has come from.
Another possible engineering approach to limiting transmission. Living with COVID and reducing harm from infection aren't contradictory.
https://www.nature.com/articles/s41598-022-08462-zMany infectious diseases, including COVID-19, are transmitted by airborne pathogens. There is a need for effective environmental control measures which, ideally, are not reliant on human behaviour. One potential solution is Krypton Chloride (KrCl) excimer lamps (often referred to as Far-UVC), which can efficiently inactivate pathogens, such as coronaviruses and influenza, in air. Research demonstrates that when KrCl lamps are filtered to remove longer-wavelength ultraviolet emissions they do not induce acute reactions in the skin or eyes, nor delayed effects such as skin cancer. While there is laboratory evidence for Far-UVC efficacy, there is limited evidence in full-sized rooms. For the first time, we show that Far-UVC deployed in a room-sized chamber effectively inactivates aerosolised Staphylococcus aureus. At a room ventilation rate of 3 air-changes-per-hour (ACH), with 5 filtered-sources the steady-state pathogen load was reduced by 98.4% providing an additional 184 equivalent air changes (eACH). This reduction was achieved using Far-UVC irradiances consistent with current American Conference of Governmental Industrial Hygienists threshold limit values for skin for a continuous 8-h exposure. Our data indicate that Far-UVC is likely to be more effective against common airborne viruses, including SARS-CoV-2, than bacteria and should thus be an effective and “hands-off” technology to reduce airborne disease transmission. The findings provide room-scale data to support the design and development of effective Far-UVC systems.
Did y'all die on 10/10?
Where's our pancoronavirus vaccine?
Where's our intranasal vaccine?
Where's all the SARS-CoV-2 Gen 2.0 tech?
The pathogen evolves swiftly to evade acquired immunity of every kind, but the urgency to counter it seems to be flagging.
Where's our Warp Speed 2.0?
Nope. Non issue
Guanfacine, developed in the lab of Amy Arnsten, PhD, Albert E. Kent Professor of Neuroscience and professor of psychology, was approved by the Food and Drug Administration (FDA) for the treatment of ADHD in 2009, but clinicians have also used it extensively off-label for other prefrontal cortical disorders such as traumatic brain injury (TBI) and PTSD. Now, Arnsten has joined forces with Arman Fesharaki-Zadeh, MD, PhD, assistant professor of psychiatry and of neurology, who has been treating long COVID patients with a combination of guanfacine and N-acetylcysteine (NAC), an anti-oxidant also used for the treatment of TBI. The combined therapy, they found, was successful in relieving brain fog for their small cohort of patients. And while larger, placebo-controlled clinical trials will be needed to establish these drugs as a bona fide treatment for post-COVID-19 neurocognitive deficits, they say patients can obtain them now if their doctors wish to prescribe them
https://medicine.yale.edu/news-artic...ovid-patients/“There’s a paucity of treatment out there for long COVID brain fog, so when I kept seeing the benefits of this treatment in patients, I felt a sense of urgency to disseminate this information,” says Fesharaki-Zadeh. “You don’t need to wait to be part of a research trial. You can ask your physician—these drugs are affordable and widely available.” Because they are FDA-approved and have been used for years, their safety for patients is established.
Interesting details on Novavax. Seems to be better than the bivalent booster and more durable than mRNA vaccines, without the unpleasant hangover.
Far-UV lighting kills microbes and is safe to use.
https://www.nature.com/articles/d41586-022-03360-w
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