I don't think this would work.
Offensively, Blair can't shoot. At All. So he does nothing to spread the floor and really has no business on the wing.
In fact, he is most effective when he is planted under the basket, hunting for boards and looking to clean up mess shots. He's not a guy you can run plays for yet, aside from a pick & roll maybe (and he's got one option on that: roll).
Defensively, faster SFs in the league like Lebron, Durant, or Odom would constantly be a step ahead of Blair on the break while he hits the boards. Not to mention the fact that they'd be much quicker afoot than him in general, and would probably either get around him with ease or force him into quick fouls. Or just back up and shoot from the perimeter, thus drawing one of our best rebounders out of the paint.
Without a jumper, it's even a stretch to call Blair a PF. At this point and with his skills, Blair is what he is: an undersized center.