You mentioned something that irks me about FO3.
I can never go very long without having to hike back to Megaton and unload the crapload of I have ac ulated while out and about. Even with the Ghoul dude in "party" and loading his ugly-ass up, I still clear a building, loot most everything and have to run back to Megaton and store in my lockers.
Moreover, maybe this has to do with your argument, but in all these types of games, I never have to (or choose to) use any of the buff "potions". I have literally hundreds of RadAway and Jet because I have never felt I needed them. I mean damn, the only thing I am using not named a Stimpak is Vodka/Scotch for the STR bonus so I can, you guessed it, carry more useless that I can never sell because vendors in Rivet City and Megaton run out of money before I even get through my "Apparel Locker" ( one locker is for crafting, one for weapons, one for apparel, the desk upstairs is for bull and the fridge downstairs is for all the special like Scrap Metal, unique outfits, named weapons, Blood Packs, PreWar Books, etc).
...and this gripe extends to all games. Like Dragon Age, all the potions, pots and bull you ac ulate is just a waste of inventory space beyond health pots and mana pots. Nature salves, Ice-this, flame-that...all crap, all never used or crafted.
Just seems to be a waste, at least they are for the type of player I am, I guess. IIRC, and honestly its been awhile, I think Oblivion was the same way.
Mass Effect, otoh, didnt have that problem and I liked it for that.
The only game I ever used that sort of stuff in was WoW, because if you didnt, you didnt stand a chance against those who did.