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If the team's best player is a perimeter player, an isolation play is preferable over a pick-and-roll play because in PNR, you are giving the defense a better opportunity to double team that best player to make a shot attempt more difficult over two players or forcing the ball out of that best player's hands when the double happens. The best (perimeter) players in the league have one-on-one ability, so you want the floor spread and the opportunity for that player to go against one-on-one defense. The rare exception is when the team's best clutch player is a guard but is more of just a shooter without great one-on-one skills, like Reggie Miller, Ray Allen, or Rip Hamilton. That's when running a play involving picks and curls makes more sense. But not when you got players with good one-on-one ability like Kobe, LeBron, Dirk, Ginobili, etc.
