BPA linked to Brain Tumors

[Agloco]

strange that it is linked to prostate cancer. I thought estrogen like substances decreased prostate cancer, like Japs with soybean consumption. I believe Japan has very little prostate cancer.

http://www.news.cornell.edu/stories/...ate.rubin.html

Using a breakthrough technology that reveals new data from 30-year-old samples, researchers led by Weill Cornell Medical College (WCMC) pathologist Mark Rubin have pinpointed the hormone estrogen as a key player in about half of all prostate cancers.

Estrogen-linked signaling helps drive a unique and aggressive form of the disease caused by a chromosomal translocation, the researchers found, which, in turn, results in the fusion of two genes.

http://onlinelibrary.wiley.com/doi/1...22534/abstract

Abstract

BACKGROUND

Through mediation of estrogen receptors, estradiol has been shown to have both carcinogenic and anti-carcinogenic effects on the prostate. We performed a population-based case–control study to investigate variants in estrogen-related genes ESR1, ESR2, CYP19A1, CYP1A1, and CYP1B1 and the potential association with risk of prostate cancer (PCa).

MATERIALS AND METHODS

We evaluated PCa risk conferred by 73 single nucleotide polymorphisms in 1,304 incident PCa cases and 1,266 age-matched controls. Analysis included stratification by clinical features and assessment of environmental modifiers.

RESULTS

There was evidence of altered risk of developing PCa for variants in ESR1, CYP1A1, and CYP1B1, however, only CYP1B1 rs1056836 retained significance after adjustment for multiple comparisons. An association with risk for more aggressive PCa was observed for variants in ESR1, ESR2, and CYP19A1, but none was significant after adjustment for multiple comparisons. There was no effect modification by obesity.

CONCLUSIONS

Germline genetic variation of these estrogen pathway genes may contribute to risk of PCa. Additional studies to validate these results and examine the functional consequence of validated variants are warranted.

http://www.earthyreport.com/site/est...e-cancer-rise/

Canadian researchers may have discovered a link between estrogen from oral contraceptives that have found its way into drinking water supplies, and a rising rate of prostate cancer in men. Researchers at Princess Margaret Hospital in Toronto examined the percentage of women using the pill, condoms, intrauterine devices, and vaginal barrier contraceptives in 87 countries, and then examined the incidence and deaths from prostrate cancer. Lead researcher, Dr. David Margel, an urologist and fellow in uro-oncology said, “Looking at these percentages, we find a strong correlation between female use of oral contraceptives at a population level and both new cases of prostate cancer and mortality from prostate cancer. This was not found among other contraceptive modes,” he said. “We also checked the percentage use of intrauterine devices or condoms or vaginal barriers and the same relation was not found.”

HOWEVER


http://www.sciencedaily.com/releases...0419150813.htm

ScienceDaily (Apr. 19, 2010) — A high level of one type of estrogen in a man's body might increase his risk of developing prostate cancer. That is one surprising conclusion from a new study which also offers another novel finding -- that high levels of the estrogen considered fuel for breast cancer might offer a protective benefit against prostate cancer.Details of the research were recently presented at the AACR 101st Annual Meeting 2010.

The health of the prostate has long been considered dependent on the level of the male hormones collectively known as androgens however, it is now recognized that estrogens and their metabolites (estrogen broken down by chemical processes in the body) play a role in its normal growth as well as in prostate cancer.

"The aim of our study was to evaluate the use of estrogen metabolites, as a marker for prostate cancer risk," says Ourania Kosti, PhD, at Georgetown Lombardi Comprehensive Cancer Center.

Which is to suggest that the science is far from settled on the matter.

[mouse]

Didn't someone post last week Science cured Cancer already?

[BlairForceDejuan]

My BPA laced water bottles contribute to working out which has got to help prevent cancer in some way...so it's all a wash.