I give to two organizations (actually raffle off a smoked brisket up here in Pa each year at my New Years party to support):
ICCAP
also give to:
American Red Cross
have been giving less and less to my church; not happy with how they've been spending money as of late - instead been sending that money as well as advice to a guy I met on a plane trip one time down to SA - he is starting churches in Maldova; and trying to teach people to (as he says) "do the business".
If you are careful, there are plenty of worthy places doing good work to give your money to.