We all know the current Spurs struggles, both on health and game... but I want to focus a bit on actual matchups.
In the last game, Pop played Tiago on Gasol and TD on Dwight. I'm not sure that's the way to go. While it's true that you want to keep TD near the basket at all times and Gasol likes to pull out more, the Lakers really have nobody that can penetrate from the perimeter on a consistent basis (MWP would be the exception, but he just barrels to the basket). Putting Tiago on Dwight makes it easier to foul Dwight without TD racking up fouls. Also Tiago has had much more difficulty trying to play outside the paint, where Gasol like to operate these days.
The rest of the Lakers are fairly average and below-average players. But they can shoot. It will be key for guys like Green, Kawhi, TP, etc to not go help or double-team. Stay in front of your guy, fight through screens and make them put the ball on the floor.
Steals and transition will be another aspect the Spurs need to focus on. Lakers like to turn the ball over, and they're pretty bad in transition D.
For the Lakers the gameplan is fairly easy: pack the paint, and make the Spurs beat you from outside. Spurs will likely run pick & roll to death, but Lakers will be happy to give up the shot every time.