I'm a noted pessimist, but my only worry is Splitter's health. Seeding, while important, isn't as crucial for a team with this much experience and resolve. The road won't faze them. Additionally, every team in the West (aside from the Warriors) is about equal in strength and similarly built, featuring a shot-blocking center, athletic PF who can hit the midrange jumper, and a good PG. 2 seed or 6th, we were pretty much playing the same team either way.
The Clippers don't overly concern me because their small forward rotation is trash (Barnes is washed up and Crawford is an inefficient chucker), which will free up Kawhi to cause maximum damage on both ends. And their SG rotation isn't too deep, either, with Red (a good shooter, but not much of a threat to beat you off the dribble and such, something the Spurs have had trouble defending from the SG position all year. Green should have little trouble staying with him) and then Doc's son behind him. Then you have DeJordan as a liability at the free throw line, which will definitely come into play. And their big rotations is ultra thin, too. Hawes, Big Baby, and nothing else.
Griffin and Paul will have to go God Mode to win this series.