I don't really get the whole hype over getting a one seed unless you're the overall #1 in the field. Tournament history is littered with twos ('04 UConn), threes (like Florida and Carmelo's Syracuse team), and fours (Arizona) taking home the le. In fact, in the last ten years, just as many non-#1's have won as #1's.
With the pod format and neutral courts, I think it's more advantageous to wind up in a 1st and 2nd round pod with three beatable teams than to sweat the seeding. Look how often low seeded tourney darlings like George Mason and Wichita State show up in the regionals because it's just a one-and-done format. When you're a top-ten team like A&M, you've got a great shot at the hardware with only fifteen other teams left standing.
A few years back when the Horns made the Final Four, they were a one seed. OU was a one as well, so there's a little precedent for the Big 12 to get two #1's. Of course, the eventual champion wound up beating UT and OU in consecutive games.