No. My biggest gripe is the two tiered system of justice that US citizens are now eligible for.
The which Obama has not only upheld, he has pioneered novel techniques of mechanized, totally extrajudicial, American justice against American citizens. Normalizing and extending the Bush security regime is a biggie.
So, apart from treating US natives as second-class citizens (or, if you like, the revival of outlawry) and putting Americans on secret kill lists, prior restraint on the internet probably comes in third for me.
It's still a biggie. It's very freaking important too. The slighting way you referenced Megaupload, as if that were a trifle, a thing not to be taken seriously, reflects poorly on the bona fides of your sympathy, but then again, it certainly isn't the only such case.
Would you like to discuss some of the others?