Dude, I went to school on the south side for 8th grade because my mom taught there. Was the only white kid to graduate from Zamora Middle School in Spring 2009. Was frequently picked on because I was smart, white, and didn't say "c*nt" or "pussy" every other sentence. Every other month someone got pregnant... my mom worked there, so I would know... and this was MIDDLE SCHOOL. Even girls I had crushes on, randomly got pregnant. And Zamora was the best middle school in South San. Dwight and the rest were much worse. I have first hand experience, and you know what else? My mom lived on the south side for 3 years as a teenager with one of my grandmother's abusive ex boyfriends.
As for the East side, I've never spent significant time there, but my mom did have to go to the teacher's workshop facility (Region 20) -- on some Saturdays -- which was located near AT&T Center. I went with her a few times to try to learn something, I guess? That area is awful. Jim street, Tom street and I forget the rest. The houses look like little shacks with wire fences, overgrown lawns and paint peeling off. Old black men limping around in rags begging for money. That's no place to build an NBA stadium, at all.
For the North side... like, 410 and 281 intersection area? That's probably the best part of SA, maybe along with the far northwest and far northeast sides (though the NE is getting too many blacks these days, though they are the most affluent blacks by far in the metro area). I-410 on the north side is where all the actual jobs are, all the tech jobs, finance jobs, office jobs for you know, actual civilized adults? There aren't a lot of good jobs in SA, but those that are... Lockheed Martin, Rackspace, USAA and the like... are all on the north side.