I'd suggest Uncharted, Uncharted 2 (can't remember the rating on these ones -- killing, of course, but I don't remember how much there is in terms of language and such), the Ratchet & Clank games, and Little Big Planet.
Might not be good for the nephews depending on age, but if you liked the PS2 God of War games you'll like the new one, too. Bioshock and Bioshock 2 are awesome shooters, but again mature. The Wolverine game was surprisingly fun (more fun than actually good) considering how crappy the movie was. And Batman: Arkham Asylum is a bit slower paced than anything mentioned above, but is a great game.

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