"If I think about it selfishly, I don't care. I am done, almost for sure. But it would be disappointing," said 35-year-old Ginobili, who is playing in his third Olympics after earning gold at the 2004 Athens Games and a bronze medal in Beijing.
"But it would be disappointing. If I was 24 right now, I would be crying in the corner that I wouldn't have this opportunity in my life.
"It's something that I wish every athlete can be part of because it's amazing. It's a wonderful experience and I'm so proud for having played in three of them. It is one of the highlights of my career."
U.S. team members Kobe Bryant, LeBron James and Kevin Durant, among many others, have also spoken out against the idea.
"It would be sad if somebody that is now 23, 22 in four years is going to be (too) old to play in the Olympics and couldn't do it," said Ginobili, who has also won three NBA les during his 10-year career with the San Antonio Spurs.