The Spurs dont have the personel to run seven seconds or less let alone "run". They dont have the dribbling, the slashing nor the defensive a en to create a "run" offense.
They will attempt to see if they can do this with Murray, but i dont believe for a second hes good enough or consistent enough for it to be a viable option.
Their best bet is to hope forbes improves, mills finds his shot back, white becomes a shooter and Derozan becoming a shot creator that can take advantage of the space he creates. All of which is a tough ask and even achived is a top 5 team in the west at best.
Derzoan is a great shot creator, but a shot creator for himself. He isnt tony or even kawhi who knew how to use spaces created by their own idnividual brilliance.
So really their best bet is to hope derozan can attack the basket enough to compliment aldridge who undoubtley is the only player the spurs should be trusting to create a system with.