Coronavirus treatments and vaccines thread

[Winehole23]

The molecular structure of HexaPro, a modified version of the SARS-CoV-2 e protein, with its six key alterations shown as red and blue spheres.Credit...University of Texas at Austin

[Winehole23]

But once Dr. McLellan and his colleagues handed off the 2P e to vaccine makers, he turned back to the protein for a closer look. If swapping just two prolines improved a vaccine, surely additional tweaks could improve it even more.


“It made sense to try to have a better vaccine,” said Dr. McLellan, who is now an associate professor at the University of Texas at Austin.

In March, he joined forces with two fellow University of Texas biologists, Ilya Finkelstein and Jennifer Maynard. Their three labs created 100 new es, each with an altered building block. With funding from the Gates Foundation, they tested each one and then combined the promising changes in new es. Eventually, they created a single protein that met their aspirations.

The winner contained the two prolines in the 2P e, plus four additional prolines found elsewhere in the protein. Dr. McLellan called the new e HexaPro, in honor of its total of six prolines.

The structure of HexaPro was even more stable than 2P, the team found. It was also resilient, better able to withstand heat and damaging chemicals. Dr. McLellan hoped that its rugged design would make it potent in a vaccine.

https://www.nytimes.com/2021/04/05/h...n-vaccine.html

[Winehole23]

Dr. McLellan also hoped that HexaPro-based vaccines would reach more of the world — especially low- and middle-income countries, which so far have received only a fraction of the total distribution of first-wave vaccines.


“The share of the vaccines they’ve received so far is terrible,” Dr. McLellan said.


To that end, the University of Texas set up a licensing arrangement for HexaPro that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties.


Meanwhile, Dr. Innis and his colleagues at PATH were looking for a way to increase the production of Covid-19 vaccines. They wanted a vaccine that less wealthy nations could make on their own.

[DarrinS]

[ChumpDumper]

Darrin's cartoons

[DarrinS]

Darrin's cartoons

Not a cartoon, dip .

[ChumpDumper]

Not a cartoon, dip .

Darrin's rage

[DarrinS]

Darrin's rage

Uh, ok. It's a video. This is my rage.

[pgardn]

only 6 months?

at LEAST 6 months. They only have so much data.

And effective against SA variant

https://abc7ny.com/pfizer-covid-vacc...ines/10466931/

The idiot was already told this.
He needs to be hit twice in the head.

[pgardn]

To that end, the University of Texas set up a licensing arrangement for HexaPro that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties.


Oh yeah.
Hook'em.

[Winehole23]

To that end, the University of Texas set up a licensing arrangement for HexaPro that allows companies and labs in 80 low- and middle-income countries to use the protein in their vaccines without paying royalties.


Oh yeah.
Hook'em.

Be killer if it's a better vaccine and cheaper to make.

[pgardn]

Be killer if it's a better vaccine and cheaper to make.

Yes sir.
Good stuff.

I like the model of the e protein btw.

[ChumpDumper]

Uh, ok. It's a video. This is my rage.

Darrin's feigned cool

You ever figure out a way to answer any questions?

[Winehole23]

Yes sir.
Good stuff.

I like the model of the e protein btw.

I hope Dr. McLellan has a good bodyguard or is one.

[ChumpDumper]

Peter Hotez is also working on a cheaper vaccine at Baylor.

[pgardn]

I hope Dr. McLellan has a good bodyguard or is one.

Maybe Gregg Abbott will come at him in Austin.
He can roll "the Guvnah" off the tower in self defense.

[Winehole23]

Peter Hotez is also working on a cheaper vaccine at Baylor.

very cool

“We created a center here in Texas to develop vaccines that the big pharma companies are not in a position to make because there's not a financial model for the shareholders,” Dr. Hotez said during a recent episode of the “AMA COVID-19 Update” about his 10 years of work with coronaviruses. He is the dean of the National School of Tropical Medicine, and professor of pediatrics and molecular virology and microbiology at Baylor College of Medicine in Houston.


“About 10 years ago, we got connected to a virology group at the New York Blood Center led by Shibo Jiang, MD, PhD, and Lanying Du, PhD, who had a pretty good idea for coronavirus vaccines,” said Dr. Hotez who is also co-director of the Center for Vaccine Development with Maria Elena Bottazzi, PhD at the Texas Children’s Hospital. “At the time, interest in coronavirus vaccines was not high. They were sort of orphaned, so we adopted it just like we adopted Chagas disease vaccines and leishmaniasis vaccines.”


“We formed a consortium, together with the Galveston National Laboratory (Kent Tseng, PhD) and Walter Reed Army Ins ute of Research,” he said.

https://www.ama-assn.org/delivering-...id-19-vaccines

[ChumpDumper]

very cool

https://www.ama-assn.org/delivering-...id-19-vaccines

Yeah I heard him talk about it on the New Abnormal podcast. That's the kind of stuff that will save the rest of the world.

[pgardn]

You can be sure the vaccination rollout would have been extraordinarily poor under Trump.

https://apple.news/AAQLJ315pQtydxXDfgqDj7Q

Another thank God Biden won.
DMC can thank himself.

[Winehole23]

suggests the US doesn't have enough vaccines yet

[Winehole23]

[SnakeBoy]

[Winehole23]

are vaccines still in short supply in the US?

[SnakeBoy]

[leemajors]

Doesn't the J&J error situation make that hard to do?