What do you mean best not miss? Cori Bush ran against Clay in 2018, lost handily but raised awareness in her district for how much of a s bag Clay is, then won this year. I'm hoping Morse does the same thing in 2022. In the limited sample we've seen, the entrenched in bents are weaker the 2nd time around after someone already tried to take them out.
Pelosi also already thinks AOC is a petulant idealist and is going to fight her tooth and nail on all progressive legislation, AOC taking a shot at her wouldn't change that.
Re Joe Kennedy/the senate - Kennedy was up 25 points in the polls when he first entered the race and proceeded to tank. Markey being an in bent was a factor, but the bigger hurdle for Kennedy is that he was an insufferable asshole who people hated the more they heard from him. He couldn't articulate why he was running for senate against someone who he ostensibly agreed with on nearly every issue.