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  1. #226
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    and no medical literature has been done to for long term effects on these drugs on healthy prepubescents, I can't find any actual trials that have measured long term effects of these drugs on healthy children.
    As far as I know, you can't prescribe them unless they have FDA approval, which involve such trials, etc, so I have to assume such studies/trials do exist.

  2. #227
    A neverending cycle Trainwreck2100's Avatar
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    As far as I know, you can't prescribe them unless they have FDA approval, which involve such trials, etc, so I have to assume such studies/trials do exist.
    they are prescribed off label

  3. #228
    my unders, my frgn whites pgardn's Avatar
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    I'm fine with using people's preferred pronouns as long as it makes grammatical sense. I'm not going to refer to someone as "they/them" since they is a plural pronoun. The concept of "non-binary" also isn't buttressed by a shred of actual science and is 100% bull .
    The idea of only binary is not buttressed by science if you are referring to sex chromosomes and development.
    If non binary, is meant to counter only binary, its fine.

  4. #229
    4-25-20 Will Hunting's Avatar
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    The idea of only binary is not buttressed by science if you are referring to sex chromosomes and development.
    If non binary, is meant to counter only binary, its fine.
    two possibilities:

    xx chromosomes
    xy chromosomes

    seems pretty binary to me

  5. #230
    Savvy Veteran spurraider21's Avatar
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    As far as I know, you can't prescribe them unless they have FDA approval, which involve such trials, etc, so I have to assume such studies/trials do exist.
    yeah but we dont have 20 year long longitudinal studies to determine every super long term potential effect meanwhile we should just let these kids suffer severe psychological distress until such time because trans people are weird and icky tbh
    Last edited by spurraider21; 06-13-2022 at 09:04 PM.

  6. #231
    Savvy Veteran spurraider21's Avatar
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    two possibilities:

    xx chromosomes
    xy chromosomes

    seems pretty binary to me
    aside from the fact that there are people with X, XXY, there are people with XY who nevertheless have female genitalia, or people with XX and grow male genitalia. so sex is not binary, but rather, bimodal

    and thats sex, not gender. somebody who is a trans woman doesnt literally believe that they have xx chromosomes, ovaries, etc. vast vast majority of our interactions where we look at a man or woman comes from social cues, not from conducting a genetic test or genital pat down

  7. #232
    my unders, my frgn whites pgardn's Avatar
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    two possibilities:

    xx chromosomes
    xy chromosomes

    seems pretty binary to me
    Yes it does but its not.

    XXY
    XXX
    X
    XYY

    And its even more confusing than this if you really want to get into it.

  8. #233
    Savvy Veteran spurraider21's Avatar
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    Yes it does but its not.

    XXY
    XXX
    X
    XYY

    And its even more confusing than this if you really want to get into it.
    graphic from scientific american


  9. #234
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    This thread is amazing. Liberals trying to cancel a reasonable liberal ( Will Hunting ) for being reasonable.

    It goes over about as well as me telling my conservative friends that Trump did a sh1t job handling COVID - or that I hope DeSantis ousts him in the primary
    Who's trying to "cancel" anybody? We're having a discussion like adults normally have. Sometimes we'll agree on some things and sometimes we don't.

    you don't need to pull the victim card for Will, tbh

  10. #235
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    they are prescribed off label
    Off-label prescribing is when a physician gives you a drug that the U.S. Food and Drug Administration (FDA) has approved to treat a condition different than your condition. This practice is legal and common. In fact, one in five prescriptions written today are for off-label use.

    https://www.ahrq.gov/patients-consum...rug-usage.html

    Welp

  11. #236
    my unders, my frgn whites pgardn's Avatar
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    graphic from scientific american

    good lord...

    And there can be all sorts of translocations between the sex chromosomes. Pieces changing places. This is where you get sex genes getting turned off or getting regulated very differently. Some of these that happen more regularly are in the diagram above.

    But I am also sure there are kids who are clearly XX, XY have no real urge for changing sex and dangle it in front of people because kids do that just to be noticed or difficult. I am also sure there are purely XX, XY kids that have no discernable sex chromosome abnormalities and really do feel like they are the wrong sex.

    Not to mention that the male parts and female parts are very much derived from the same basic developmental parts. its just when they are fully developed they look so different you would never know it.

    SJ Gould put this in a series that used to be in Natural history. He has books full of biological and evolutionary confusion and tries to explain these through Natural History. I got the whole set from my father.

    The one I was looking for was about sex organs in hyenas as a model for the confusion of just using actual parts.
    Now that Gould is long gone and we have gene sequencing and location this is outdated but it served its purpose at the time.

    https://www.zoology.ubc.ca/~bio336/B...dHyena1981.pdf I have this in article form in one of his many collections from Natural History.

  12. #237
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    yes, decades. imagine we waited decades before we started giving people smallpox or polio vaccinations. or more recently, covid vaccines. its just poor practice and impractical. as of now theres no data to suggest it causes long term fertility issues, while the limited data we have now suggests that there arent any issues. hormone replacement therapy is quite different. but weighing that against the proven mental health benefits is something that every physician will and should do
    You're flailing now

    First you cherry pick from your own article that says there is no good science on the effectiveness of tranny treatments (ignored that part of course), then you moved to we don't have time to study cuz lives (ignoring there is already proven psychiatric treatments available), and now it's whatabout smallpox or polio.

  13. #238
    A neverending cycle Trainwreck2100's Avatar
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    Off-label prescribing is when a physician gives you a drug that the U.S. Food and Drug Administration (FDA) has approved to treat a condition different than your condition. This practice is legal and common. In fact, one in five prescriptions written today are for off-label use.

    https://www.ahrq.gov/patients-consum...rug-usage.html

    Welp
    so when i said earlier about "valium for headaches, a cast for some other thing etc..."

    you said "I'd find another doctor"

    But why would you do that if you are fine with off label prescription? I only ask because that's where that comment came from.

  14. #239
    Savvy Veteran spurraider21's Avatar
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    You're flailing now

    First you cherry pick from your own article that says there is no good science on the effectiveness of tranny treatments (ignored that part of course), then you moved to we don't have time to study cuz lives (ignoring there is already proven psychiatric treatments available), and now it's whatabout smallpox or polio.
    study showed efficacy for sure. Reduced severe psychological distress, suicide ideation, etc. post hoc data showed it significantly reduces suicide attempts.

    and yeah i will just about always say it’s really dumb to withhold the use of treatments that work because we don’t have 20-30 year long longitudinal studies first. Terrible practice and it’s not a standard we would use for literally any other medical treatment

  15. #240
    A neverending cycle Trainwreck2100's Avatar
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    study showed efficacy for sure. Reduced severe psychological distress, suicide ideation, etc. post hoc data showed it significantly reduces suicide attempts.

    and yeah i will just about always say it’s really dumb to withhold the use of treatments that work because we don’t have 20-30 year long longitudinal studies first. Terrible practice and it’s not a standard we would use for literally any other medical treatment
    post hoc data doesn't apply to children only someone who has completed all their surgeries. So Reduced severe psychological distress, suicide ideation, doesn't mean it saved their lives.

  16. #241
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    so when i said earlier about "valium for headaches, a cast for some other thing etc..."

    you said "I'd find another doctor"

    But why would you do that if you are fine with off label prescription? I only ask because that's where that comment came from.
    Because the expectation is that doctors are educated to know which drugs work for given diagnosis.

    As such, a doctor that's prescribing a cast to treat asthma clearly doesn't know what he's doing, if he/she has a doctoral degree at all. It also expose them to malpractice, which can be the end of their medical license and career.

    I should also add that even for off-label use, you still would need to prescribe a drug that has been explicitly approved by the FDA to use in children of certain age, you can't escape that.

    It's probably the main reason some of these drugs cannot be administered until the children are 16+ years old.

  17. #242
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    You're flailing now

    First you cherry pick from your own article that says there is no good science on the effectiveness of tranny treatments (ignored that part of course), then you moved to we don't have time to study cuz lives (ignoring there is already proven psychiatric treatments available), and now it's whatabout smallpox or polio.
    You're flailing now.

    Old Joe broke you.

  18. #243
    Savvy Veteran spurraider21's Avatar
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    post hoc data doesn't apply to children only someone who has completed all their surgeries. So Reduced severe psychological distress, suicide ideation, doesn't mean it saved their lives.
    No . Children aren’t the one getting bottom surgery. Will’s claim was that bottom surgery not only didn’t help suicide but made it worse.

  19. #244
    my unders, my frgn whites pgardn's Avatar
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    You're flailing now

    First you cherry pick from your own article that says there is no good science on the effectiveness of tranny treatments (ignored that part of course), then you moved to we don't have time to study cuz lives (ignoring there is already proven psychiatric treatments available), and now it's whatabout smallpox or polio.
    Is this the sending of said tranny to a religious school to be turned in the right direction treatment, just talk them out of it?
    I am sure there are some kids and young adults who want to play games and be different just to worry their parents.
    But when a kid commits suicide... it was all just a big joke I guess? Like commits suicide because they really dont feel what they are told to be so they find a way out of being a worthless oddity.

  20. #245
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    study showed efficacy for sure. Reduced severe psychological distress, suicide ideation, etc. post hoc data showed it significantly reduces suicide attempts.

    and yeah i will just about always say it’s really dumb to withhold the use of treatments that work because we don’t have 20-30 year long longitudinal studies first. Terrible practice and it’s not a standard we would use for literally any other medical treatment
    Still cherry picking the one study in your own article while ignoring the mention of the other studies that did not show efficacy of these treatments.

    Still ignoring that psychiatric treatment is a proven option. Why is that? I asked you earlier if any physical changes were needed and you made the case that gender dysphoria is a purely psychiatric disorder. Why now act like psychiatric treatment doesn't exist and they'll die without the unproven physical treatments at $70k a pop? Doesn't make sense.

  21. #246
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    You're flailing now.

    Old Joe broke you.
    lol you're so angry at me

  22. #247
    Veteran Th'Pusher's Avatar
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    lol you're so angry at me
    Lol. You’re not to be taken seriously. You’re just here for the lulz.

    And you let dr boss peg you.

  23. #248
    Savvy Veteran spurraider21's Avatar
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    Still cherry picking the one study in your own article while ignoring the mention of the other studies that did not show efficacy of these treatments.

    Still ignoring that psychiatric treatment is a proven option. Why is that? I asked you earlier if any physical changes were needed and you made the case that gender dysphoria is a purely psychiatric disorder. Why now act like psychiatric treatment doesn't exist and they'll die without the unproven physical treatments at $70k a pop? Doesn't make sense.
    Nobody had presented any study to the contrary

  24. #249
    🏆🏆🏆🏆🏆 ElNono's Avatar
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    lol you're so angry at me
    lol you're so angry at Old Joe

  25. #250
    right about pizzagate Blake's Avatar
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    Just thought I'd share. I'll believe this article before I believe some cheesy movie and a few posters questioning the long term effects.

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