Ok so how about this:
Put out his eyes, cut out his tongue, destroy his sense of hearing, cut off all his arms and legs(or sever the nerves that control them at the spinal cord), and if there's any way possible get rid of his sense of touch as well...
and then keep him alive via intravenous feeding for as long as is humanly possible? With the caveat that he is trapped completely in his own mind and unable to interact with anything or anyone else?

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In his latest trip outside of the bounds of the universe, he was able to determine that there is, indeed, no . No word on how he was able to determine this.