For a semi elite QB like Romo/Schaub, if you can give up Ben + someone who'd sit on your bench more often than not, do. The way I see it, that is an overall upgrade to your starting lineup which means it'll lead to more points every week. Losing a bench player might hurt you during a couple bye weeks but the upgrade at QB is worth it.
For an elite QB like Vick/Rodgers, you would probably have to give up so much it wouldn't be worth it until someone got desperate. From my experience, unless you have an idiot in your league, almost no trades happen involving players taken early before the first few weeks of the season are over and someone starts 0-3 or 1-2 w/ a significant injury.

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