Disabling VM is not a good idea on modern OS'es. If anything, you want to have a faster drive, let me explain why.
Modern OSes will use up all the RAM you put at their disposal. That's because they use any unused RAM as disk cache. But it will release it to apps as soon as is needed.
Furthermore, OSes in this day and age suspend and swap out processes that are hidden and are not doing compute or server tasks. This is a good thing. It gives active apps have more RAM and compute cycles. Once all active processes do eat up all RAM, then you'll inevitably hit paging, and things will slow down (including the fact there's not enough RAM for a disk cache, which really makes paging slow).
Now imagine if there's no VM available. Processes can be suspended, but they must remain in memory. That means more memory fragmentation and potentially less RAM available to all processes, including the front most process.
I say "imagine", because you really can't turn off Virtual Memory on Windows. What you're allowed to control (whether you have a pagefile or not, and what size is it) is only for "private commited" memory, one "kind" of memory, but will likely cause other type of memory (ie: mapped memory) to swap out more often. That's why, if you're really short on memory and you suspect you'll page out, a faster drive makes more sense.
Here's a good writeup about the misconceptions of Virtual Memory on Windows:
http://azius.com/blog/pagefile-yes1/