Monthly isn't so bad. For my dad, I have to do them weekly, along with state (CA) and God forbid if you're late. I also have to do Sales Tax (CA).
If you're not taking advantage of EFTPS, TWC, and I highly recommend it. Also to file the 941 and 940, I use a software company that only charges $25/year. Well worth it and less mistakes (especially the 940, I can never remember how to do it and then they had the nerve to change it last year

). Social Security will let you file directly up to 20 employees (you have to put in the info) and you can print out the W-2s from their website. For my dad I have to file via magnetic media and I also file 1099s that way.