Pop might want to rest Ginobili (after all, he had a concussion the other night, right?), but he should try to win this one.
1) They would completely control their own fate as #1. And a first round against Jazz or Suns would be easieer than facing Dallas or Denver.
2) The lakers are unlikely to end up 4 anyway, if anything because they might not want to face the Spurs anytime, having been beaten down twice and weaknesses exposed, and they'd be going against Memphis, which matches up very well against their bigs. It would probably be a long, tough series for them.