I don't know all the biological science between thse, but what I gather, regular table sugar and HFCS have the same two molecule components. The difference is table sugar is made from sugar cane, beets, etc, and the fructose glucose content are a perfect 50%/50%. It is a more stable molecule and not absorbed in the stomach, but requires metabolism in the small intestine. This leads to positive nutrition for the gut flora to digest our foods. HFCS on the other hand are not in this complimentary 50/50 mix, processed to enhance sweetness, and much of the molecules break down in the stomach, being more immediately dissolved in our bloodstream rather than being broken down before entering the bloodstream. Once the glucose-fructose bond is broken, it can directly pass into the blood. Probably why it is sweeter also. Breaks down more readily in out mouth.