Coronavirus is one mutation away from infecting millions

[ChumpDumper]

https://www.whitehouse.gov/lab-leak-true-origins-of-covid-19/

:lmao

[Thread]

:lmao

[Winehole23]

no one has ever propagandized the White House quite like Trump

but no president has attempted to control the whole of government like Trump either

nor to rule by decree like Trump

[Thread]

no one has ever propagandized the White House quite like Trump

but no president has attempted to control the whole of government like Trump either

nor to rule by decree like Trump

You ain't whistlin' Dixie, dad.

It's a revenge tour, just like I'd hoped & prayed. He's absolutely nothing to lose. And he's in full recognition of that fact.

[Winehole23]

https://i.pinimg.com/originals/f6/88/a8/f688a84db4fa2ca444f9a77c8f565105.jpg


Long COVID is common, affecting up to 10% to 20% of children with a history of COVID-19. With almost 6 million US children potentially affected, this is higher than the number of children with asthma, the most common chronic health problem in children.https://jamanetwork.com/journals/jamapediatrics/fullarticle/2834486

[GAustex]

Asshole23 better get out there like a good lemming and booster up

[ChumpDumper]

Asshole23 better get out there like a good lemming and booster up

Are you a good little polio lemming?

Don't lie.

[koriwhat]

no one has ever propagandized the White House quite like Trump

but no president has attempted to control the whole of government like Trump either

nor to rule by decree like Trump

You're kidding right Mr Bias cultist? Biden literally tried to rule by decree, EO, and just flat out stating amendments are pulled straight out of his ass while ignoring the SC rulings time and time again.

You're such a disingenuous propagandist.

[koriwhat]

Lol Ministry of Truth... yet Trump's the propagandist here. :lmao

[Winehole23]

Asshole23 better get out there like a good lemming and booster upold fangled protein based

Novavax

I'm good for now

[Winehole23]

thx for your concern!

[Winehole23]

evidence that COVID damages the brain continues to pile up


Reduced metabolism often serves as a marker of neuronal dysfunction, where brain cells become less active and consume less glucose50 (https://www.nature.com/articles/s41598-025-04815-6#ref-CR50). In contrast, a decrease in alpha power, typically associated with relaxed wakefulness and cognitive processing, can signal disrupted brain activity, as often seen in the early stages of cognitive decline51 (https://www.nature.com/articles/s41598-025-04815-6#ref-CR51). Both hypometabolism and changes in spectral power are indicators of underlying neuronal stress or damage52 (https://www.nature.com/articles/s41598-025-04815-6#ref-CR52),53 (https://www.nature.com/articles/s41598-025-04815-6#ref-CR53). Our results reinforce the idea that cognitive decline in long COVID may be linked to both metabolic and electrical dysfunction in the brain.https://www.nature.com/articles/s41598-025-04815-6

[DarrinS]

evidence that COVID damages the brain continues to pile up

https://www.nature.com/articles/s41598-025-04815-6

Obviously damaged your brain. No one cares anymore.

[GAustex]

Obviously damaged your brain. No one cares anymore.

Lol

[ChumpDumper]

evidence that COVID damages the brain continues to pile up

https://www.nature.com/articles/s41598-025-04815-6

Explains Darrin and the other Trumptards nicely.

Black President™ made them lose their minds. COVID assured they would never get them back.

[koriwhat]

Obviously damaged your brain. No one cares anymore.

It's his echo chamber as is the rest of the Pol forum. :lol

[Winehole23]

The risk for long COVID and vascular damage accumulate with reinfection

RFK Jr. sh!tcanning US work on mRNA vaccines will cause enormous harm and prevent vaccines already in the pipeline for AIDS and cancer


A new finding of accelerated vascular aging after Covid adds to the knowledge base of the toll of this virus on our blood vessels, especially our arteries. Much of the focus of Covid has been on the heart per se, with less attention to the impact on arteries and blood vessels (veins, microvasculature) In this Ground Truths, I’ll review the 3 dimensions for how our understanding Covid’s effect on arteries has evolved: (1) Endothelial Inflammation; (2) Promoting Atherosclerosis; and (3) Accelerating Aging


1. Endothelial Inflammation

Since the early days of the pandemic, inflammation of the endothelium, the lining of the blood vessel wall, was recognized. Endotheliopathy (https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30216-7/fulltext) (or endotheliolitis) was demonstrated in post-mortem specimens, schematically shown below (https://pubmed.ncbi.nlm.nih.gov/32619412/), with activated platelets and proteins that operate in the coagulation cascade to increase the risk of clotting (coagulopathy). The inflammation could be engendered by either direct infection the virus into the blood vessel wall or the inflammation mediators (cytokines, chemokines) released throughout the body from Covid. The process leading to an inflammatory endothelium underlies clinical events such as heart attacks and strokes.

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Indeed, Libby and Luscher authored a perspective entitled “COVID-19 is, in the end, an endothelial disease” (https://pubmed.ncbi.nlm.nih.gov/32882706/) making a strong case in the early months of the pandemic, when the primary focus was just on the respiratory system— that the blood vessel lining effect of Covid was central to its morbidity and mortality.

Since the many studies have added to the mix, showing the Covid-induced endothelial inflammation leads to leaky blood vessels (increased vascular permeability) (https://elifesciences.org/articles/69314), abnormal vasomotor tone or dysregulation (https://pubmed.ncbi.nlm.nih.gov/36250654/). that it can increase the risk (https://pubmed.ncbi.nlm.nih.gov/36206332/) of hypertension (https://saluddigital.com/wp-content/uploads/2022/10/endotelio-y-covid.pdf), has further exacerbation by abnormal lipids (https://www.jci.org/articles/view/183777), and results in reduction of myocardial blood flow (https://pubmed.ncbi.nlm.nih.gov/36250654/). Of course, the effects were not confined to arterial endothelium, but also seen in veins with risk of deep vein thrombosis, and the microvasculature (https://academic.oup.com/ehjcimaging/article/24/11/1544/7186983). Our review of Long Covid (https://www.nature.com/articles/s41579-022-00846-2) cited the role of blood vessel inflammation and its sequelae as one of the principal mechanisms for this condition.


2. Coronary Atherosclerosis






It took longer for us to understand had Covid promoted atherosclerosis, even though an increase risk of heart attacks was noted in the first year of the pandemic. Now several studies in experimental models and patients (https://www.jacc.org/doi/10.1016/j.jacadv.2024.101107) have demonstrated this effect, not only in the progression of atherosclerosis but also in its initiation (schematic below, Figure (https://www.jacc.org/doi/10.1016/j.jacadv.2024.101107)).

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(https://substackcdn.com/image/fetch/$s_!l3m4!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F6664930 9-5a84-4f0f-9e94-426a6f5c1de0_3728x3204.heic)
Specifically, in post-mortem coronary artery specimens (https://www.nature.com/articles/s44161-023-00336-5) in confirmed severe Covid patients there was detection of the virus in macrophages and foam cells along with the finding of the SARS-CoV-2 antisense strand replicating In these cells (https://www.nature.com/articles/s44161-023-00358-z), composing an infection fo the blood vessel wall, marked inflammation, and potentiation of plaque instability (schematic below).

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Recently, from patients with repeat CT coronary angiograms (https://pubs.rsna.org/doi/10.1148/radiol.240876) (690 with Covid, without hospitalization nad 113 controls, without Covid), there was evidence of more arterial plaque progression (left panel, for one metric below) to high-risk non-calcified plaques, increased inflammation, and more major adverse cardiovascular events (MACE) (right panel) among those with Covid.

https://substackcdn.com/image/fetch/$s_!mSN6!,w_1456,c_limit,f_auto,q_auto:good,fl_pro gressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fdb134f2 0-54e4-4c9f-9712-2bc0a04ed2fe_1862x610.heic





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The accompanying editorial to this paper was subtitled (https://pubs.rsna.org/doi/10.1148/radiol.243767) “An Early Warning of a Potential Public Health Crisis.”

Share Ground Truths (https://erictopol.substack.com/?utm_source=substack&utm_medium=email&utm_content=share&action=share)
3. Acceleration of Vascular Age






The new study reported 17 August in the European Heart Journal (https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf430/8236450)was a big project involving 18 countries, 38 centers, and enrollment of over 2,000 participants to measure (on a repeat basis at baseline, 6 months and 1 year) carotid artery pulse wave velocity (PWV), a metric that is an indicator of arterial stiffness..

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There were many important findings from this work. The acceleration of early (accelerated) vascular aging (EVA) was not proportionate to severity of COVID. Although participants who required ICU hospitalization had an estimate of 10 years of EVA, those who were not hospitalized had the same—5 years of accelerated arterial aging— as participants who did require hospitalization. The EVA effect was only significant in women and there was a statistically significant interaction term for Sex X EVA. Symptoms of Long Covid were linked to EVA and vaccination was associated with protection from EVA (graphs below, respectively). All of the analyses were adjusted for potential confounders. Some people with early EVA had resolution at 1-year follow-up. There was no assessment for reinfection and this prospective study was largely conducted early in the pandemic. The accompanying editorialist wrote: "The..study makes the case that Covid has aged our arteries, especially for females." (https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf590/8236451)

https://substackcdn.com/image/fetch/$s_!SQGV!,w_1456,c_limit,f_auto,q_auto:good,fl_pro gressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F683031d a-befd-459d-afa9-d43f63521290_3020x888.heic (https://substackcdn.com/image/fetch/$s_!SQGV!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F683031d a-befd-459d-afa9-d43f63521290_3020x888.heic)







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[Winehole23]

Bad flu season, the flu vaccine prediction was off, H3N2 ended up being the dominant strain

England is mightily afflicted, NHS is experiencing COVID like stress atm, there seems to be a relative paucity in the English language press, I see many international mentions of H3N2

I'm fully flu vaxxed but will mask up (3m Aura Trifold) strategically to attempt to protect myself and others, as I did with COVID

[Winehole23]

too bad MAHA rules mRNA vaccines out

this isn't the only example, there's a pancreatic cancer vax affected by this too


ConclusionsThe modRNA vaccine had statistically superior efficacy over the control vaccine, with greater immune responses to A/H3N2 and A/H1N1 strains, but was associated with more reactogenicity events. (Funded by Pfizer; C4781004 ClinicalTrials.gov number, NCT05540522 (http://clinicaltrials.gov/show/NCT05540522).)
https://www.nejm.org/doi/full/10.1056/NEJMoa2416779

[DarrinS]

I'm fully flu vaxxed but will mask up (3m Aura Trifold) strategically to attempt to protect myself and others, as I did with COVID

:lol

[ChumpDumper]

:lol

Did you ever find the courage to state your AIDS/COVID conspiracy theory?

[Winehole23]

I must be one of the lucky 5%

Happy New Year to you if you are too



https://cdn.bsky.app/img/feed_fullsize/plain/did:plc:gwqfwdnfwdlcpkr457l2udwh/bafkreiaxdepklretgrevjw75q4sbkbgpfof25fcnwe5azz7do jee2i4r44@jpeg

[Winehole23]

COVID is still a killer



In this new study, the CDC authors analyzed data from COVID-NET, a surveillance program keeping track of covid-related hospitalizations. They focused on two time periods, about a year each: October 2022 to September 2023 and October 2023 to September 2024.

Based on this data, the researchers estimated that covid-19 sickened 43 million Americans between 2022 and 2023; it also sent 10 million people to their doctor, caused 1.1 million hospitalizations, and killed 101,300 people. Between 2023 and 2024, they estimated that covid-19 sickened 33 million Americans, caused 7.7 million outpatient visits, 879,100 hospitalizations, and 100,800 deaths.

These numbers are far below the peak of the pandemic in the U.S. In 2021, for instance, covid-19 officially killed (https://www.cdc.gov/nchs/nvss/vsrr/covid19/index.htm) over 400,000 Americans. But the annual death toll of covid-19 between late 2022 and 2024 likely still eclipsed that of any other single infectious disease (last winter’s especially bad flu season (https://www.cdc.gov/flu-burden/php/data-vis/2024-2025.html) being a possible exception).

“Despite declines in illnesses, outpatient visits, and hospitalizations from 2022-2023 to 2023-2024, covid-19 imposed a large annual impact in the US.,” the authors wrote in their paper, published (https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/jamainternmed.2025.7179?guestAccessKey=c26397f8-3193-499d-a048-281b78b4d8b6&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=010526) Monday in JAMA Internal Medicine.
https://gizmodo.com/covid-19-is-still-killing-a-disturbing-number-of-americans-study-finds-2000705483